| ends at Commercial Way (55 (US 19)) | |
| Hernando | Cortez Blvd |
| Sumter | SR 50 |
| Lake | SR 50, W Broad St, [W Orange St, E Orange St](W Broad St, E Broad St), SR 50 |
| Orange | W Colonial Dr, E Colonial Dr, Cheney Hwy |
| Brevard | Cheney Hwy, Orlando Rd |
| ends at US 1/Washington Ave S (5 (US 1)) | |
| ends at Cortez Blvd/Cobb Rd (50) | |
| Hernando | W Jefferson St, [N Mildred Ave, Broad St](W Jefferson St, E Jefferson St), E Jefferson St |
| ends at Cortez Blvd/Jasmine Dr (50/700) | |
| ends at 2nd St W | |
| Taylor | 1st Ave S, Riverside Dr, 4th Ave S, 15th St E, SR 51 |
| Dixie | SR 51 |
| Lafayette | SR 51, Fletcher St, SR 51 |
| Suwannee | SR 51, Irvin Ave, 11th St SW, Ohio Ave, US 129 |
| Hamilton | US 129 |
| ends at US 41 (25/100 (US 41/129)) | |
| ends at US 19 (55 (US 19)) | |
| Pasco | Gulf Blvd, SR 52, 21st St, Meridian Ave |
| ends at Old Lakeland Hwy (533 (US 98/301)) | |
| ends at I-10 (8 (I-10)) | |
| Madison | SR 53, S Duval St, E Base St, W Base St, N Washington St, SR 53 |
| enters Georgia (333) | |
| ends at US 19 (55 (US 19)) | |
| Pasco | Gunn Hwy, SR 54, 5th Ave |
| ends at Gall Blvd (39 (US 301)) | |
| ends at 14th St W (45/684 (US 41/41B)) | |
| Manatee | 44th Ave W, 1st St, US 41, Bayshore Rd, US 19, Sunshine Skyway |
| Hillsborough | Sunshine Skyway |
| Pinellas | Sunshine Skyway, 34th St S, 34th St N, US 19 |
| Pasco | Magnolia Ave, US 19 |
| Hernando | Commercial Way |
| Citrus | US 19, S Suncoast Blvd, N Suncoast Blvd, US 19 |
| Levy | US 19, S Main St, N Main St, N Young Blvd, US 19 |
| Gilchrist | US 19 |
| Dixie | US 19, Main St, US 19 |
| Taylor | US 19, S Jefferson St, N Jefferson St, US 221 |
| Madison | US 221, US 90, US 221 |
| Jefferson | US 221 |
| enters Georgia (76 (US 221)) | |
| ends at US 41 (20 (US 19/27)) | |
| Jefferson | US 19, S Jefferson St, N Jefferson St, US 19 |
| enters Georgia (3/300 (US 19)) | |
| ends at US 98 (30 (US 98)) | |
| Jefferson | SR 59 |
| Leon | SR 59 |
| ends at Mahan Dr (10 (US 90)) | |